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KMID : 0043320090320050677
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Archives of Pharmacal Research
2009 Volume.32 No. 5 p.677 ~ p.683
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Cognitive-enhancing Activity of Loganin Isolated from Cornus officinalis in Scopolamine-induced Amnesic Mice
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Kim Young-Choong
Oh Tae-Hwan
Jang Young-Pyo
Kim Seung-Hyun
Sung Sang-Hyun
Lee Ki-Yong
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Abstract
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We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) gnificantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.
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KEYWORD
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Cornus officinalis, Loganin, Scopolamine-induced amnesic mice, Passive avoidance test, Morris water maze test, Acetylcholinesterase
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